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[논문-IMGT] Evading Doxorubicin‐Induced Systemic Immunosuppression Using…

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  • Date : 22-12-01 08:37
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"Evading Doxorubicin‐Induced Systemic Immunosuppression Using Ultrasound‐Responsive Liposomes Combined with Focused Ultrasound"

 

 Pharmaceutics 2022, 14, 2603. 

https://doi.org/10.3390/pharmaceutics14122603

 

  Published: 25 November 2022 

  Jeongjin Lee, Wooram Um, Hyungwon Moon, Hyeyeon Joo, Yeari Song, Minsung Park, Been Yoon, Hyun-Ryoung Kim, and Jae Hyung Park


[Abstract]

Doxorubicin (DOX) is a representative anticancer drug with a unique ability to induce

immunogenic cell death of cancer cells. However, undesired toxicity on immune cells has remained

a significant challenge, hindering the usage of DOX in cancer immunotherapy. Here, we report

a combined therapy to avoid the off-target toxicity of DOX by adapting ultrasound-responsive

liposomal doxorubicin and focused ultrasound exposure. Histological analysis demonstrated that

the combined therapy induced less hemosiderosis of splenocytes and improved tumor infiltration

of cytotoxic T lymphocytes. Additionally, in vivo therapeutic evaluation results indicate that the

combined therapy achieved higher efficacy when combined with PD-1 immune-checkpoint blockade

 therapy by improving immunogenicity.


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