Therapeutic Focused Ultrasound for enhanced anticancer drug delivery
Our technology utilizes therapeutic focused ultrasound (FUS) to temporarily disrupt tumor vasculature and cell membranes, thereby enhancing the delivery and penetration of anticancer drugs into tumor tissues. This approach improves therapeutic efficacy while minimizing systemic toxicity, offering a promising platform for next-generation cancer treatment.
Mechanism
The technology utilizes focused ultrasound (FUS) to deliver controlled acoustic energy to targeted tumor regions. The ultrasound waves generate microbubbles, which induce temporary and localized permeabilization of tumor vasculature and cell membranes through stable and inertial cavitation effects. This process enhances the penetration and accumulation of anticancer drugs within tumor tissues, overcoming biological barriers that typically limit drug delivery. The result is improved therapeutic efficacy, reduced systemic toxicity. Additionally, the platform is designed to be non-invasive, repeatable, and compatible with existing chemotherapy or immunotherapy regimens, making it an attractive solution for next-generation precision oncology treatments.
Cavitation
Cavitation refers to the formation of voids within a fluid caused by pressure changes resulting from variations in flow velocity. When a liquid moves rapidly and its pressure drops below its vapor pressure, vapor bubbles are generated within the fluid.
